Breast cancer awareness and breast self-examination in Northern Saudi Arabia. A preliminary survey

To elicit knowledge of breast cancer, perception of occurrence, and behavior in relation to breast self-examination [BSE]. A cross-sectional survey was carried out at the Department of Pathology, Medical College, University of Hail, Hail, Kingdom of Saudi Arabia for local occupants from Hail city and its rural neighborhood between September 2010 and February 2012. A personal interview-administered descriptive questionnaire and both descriptive and inferential statistics were used. A total of 1000 participants agreed to be involved, out of which 87.7% were females, 7.2% were males and 5.1% had undisclosed gender. The age range for participants was 12-66 years. Out of all participants, 44% did not know that breast cancer is an abnormal growth and 78% failed to recognise its multi-factorial nature, with "Increased age" being the least recognised single risk factor 4.8%. Scores showed that 61.5% had a low level of breast cancer related knowledge. Out of the participants who knew of someone who had breast cancer 73%, 50.1% said the disease was discovered at a "Late stage" mainly by "Chance". Data for BSE indicated that 50.1% of female participants >16 years old did not practice BSE, and "Fear" was the main declared perceived reason. This study demonstrates a low level of fundamental knowledge of breast cancer and fear to practice BSE

Autoimmune thrombocytopenia. Is it a different disease or different aspects of a single disease?

To evaluate the association between autoimmune thrombocytopenia with other autoimmune disorders, to show if they are different autoimmune diseases or one disease with different presentations at the same time, and to study the effect of treatment on platelet count in different thyroid condition. In this retrospective study, we included 141 patients with thrombocytopenic purpura. The result of thyroid function test, thyroid autoantibodies, Coombs' reactivity, anti-nuclear antibody, and double-stranded DNA were analyzed. This study was conducted in the Clinical Hematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia between June 2003 and August 2010. There were 51 [36.2%] patients with laboratory evidence of autoimmune disease, 13 [9.2%] with hypothyroidism, and 6 [4.3%] with hyperthyroidism. In addition, 5 [3.5%] patients showed laboratory evidence of Evan syndrome and 3 [2.1%] patients had isolated positive thyroid antibodies. There was non-significant difference [p=0.61] in platelets count after one month of treatment of patients with different thyroid condition. Immune thrombocytopenia is associated with evidence of different autoimmune disease or a combination of them, which may appear at presentation or during the course of disease giving evidence that they are different manifestations of a single disease. Screening patients for antithyroid antibodies would identify a patient at risk of developing overt thyroid disease. These patients may be further screened with a thyroid-stimulating hormone assay to detect subclinical thyroid disease

Genotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Saudi Arabia

To analyze antiretroviral drug resistance and determine the genotype of human immunodeficiency virus [HIV]-l in Saudi patients by sequencing an amplified region of the viral pol gene. This retrospective study analyzed data from plasma samples submitted for genotypic drug sensitivity monitoring. Samples were analyzed at the Special Infectious Agent Unit, King Fahd Medical Research Center of King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from August 2004 to June 2009. The Viroseq2.5 kit [Celera/Abbott] was used with ABI Prism 3100 sequencer. All patients were Saudi nationals and were on antiretroviral therapy, some experiencing treatment failure. Based on protease region [PR], genotypes of 63 samples were as follows: C:22, G:21, B:9, CRF02_AG:5, D:3, A:l, F:l, and J:l. Based on reverse transcriptase region [RT], genotypes were as follows: C:23, G:24, B:9, CRF02 AG: 2, D:2, A:l, and F:l. Antiretroviral susceptibility testing results were as follows: 52% of the isolates were susceptible to all 3 major classes of antiretroviral drugs used, 41% had mutations known to confer high level resistance to one or more of the nucleoside analogue reverse transcriptase inhibitors, 16% had mutations known to confer high level resistance to non-nucleoside analogues reverse transcriptase inhibitors, 13% had mutations known to confer high level resistance to one or more of the protease inhibitors [PI]. Most isolates were susceptible to 2 or at least one class of antiretroviral, and only 3% of the isolates had resistance to several members of all 3 classes. Antiretroviral resistance is not uncommon in Saudi patients on antiretroviral therapy